Sponge compound inspires new approach to chronic inflammation

A compound from an Australian sea sponge could form the basis for new treatments for chronic inflammation, ORF reported. Researchers at the University of Graz and the University of Innsbruck are developing a synthetic active ingredient intended to combat inflammation rather than only relieve its symptoms.

Chronic inflammatory conditions such as rheumatism, diabetes and asthma can place a considerable burden on those affected. Existing treatments generally focus on easing symptoms.

The research was prompted by the discovery of a substance from an Australian sea sponge of the genus Spongia. Andreas Köberle of the University of Graz said the compound could help researchers better understand the mechanisms involved and the potential of the approach.

The team is working on a synthetic ingredient based on the sponge compound that would target the underlying causes of inflammation. The researchers aim to use metabolic dysregulation to reprogramme the body’s processes.

The sponge substance is serving only as inspiration for the research. The synthetic approach is intended to produce enough material in the laboratory without harvesting large quantities from marine ecosystems, Köberle said.

The researchers hope to begin a clinical trial in humans, but that could still be several years away. They say the approach could eventually offer new options for treating chronic inflammatory diseases.